‘Cancerland’ Review: Reason to Hope

“For all the insight he offers into the hard science and thorny logistics of studying cancer, Dr. Scadden’s most moving passages consider the effect of the disease on the people who suffer from it and those who care for them.” ―The Wall Street Journal Reviews & Acknowledgements: Wall Street Journal Nature International Journal of Science […]

Tackling blood diseases, immune disorders

Harvard University has completed a license agreement with Magenta Therapeutics, a startup company recently launched in Cambridge, for a portfolio of technologies with the potential to transform blood stem cell transplants from a “treatment of last resort” into a safer, more efficient therapy for patients with blood diseases and immune disorders. To date, even at […]

Colorful clones track stem cells

Harvard Stem Cell Institute (HSCI) researchers have used a colorful cell-labeling technique to track the development of the blood system and trace the lineage of adult blood cells traveling through the vast networks of veins, arteries, and capillaries back to their parent stem cells in the marrow. Developed at Harvard’s Center for Brain Science, the […]

New strategy identified for treating acute myeloid leukemia

A multi-institutional academic and industry research team led by investigators from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute has identified a promising new approach to the treatment of acute myeloid leukemia (AML). In their report published online in Cell, the investigators identify a crucial dysfunction in blood cell development that underlies AML and […]

David Scadden, MD, to Present the 2016 American Society of Hematology E. Donnall Thomas Lecture

(WASHINGTON, August 4, 2016) The American Society of Hematology (ASH) will honor David Scadden, MD, of Massachusetts General Hospital and Harvard Medical School with the 2016 E. Donnall Thomas Lecture and Prize for his work on the bone marrow hematopoietic microenvironment. This lectureship and prize is named after the late Nobel Prize laureate and past president […]

About the cover: Nature Biotechnology

A scanning electron micrograph of bone tissue. The bone marrow (orange) provides the niche for hematopoietic stem cells. Palchaudhuri et al. describe an antibody-based agent for depleting cells in the bone marrow before hematopoietic stem cell transplantation (p 738). Image credit: Steve Gschmeissner, Science Source.   See source.

Making bone marrow transplants safer

Harvard Stem Cell Institute (HSCI) scientists have taken the first steps toward developing a treatment that would make bone marrow blood stem cell transplantation safer, and as a result, more widely available to the millions of people living with blood disorders such as sickle cell anemia, thalassemia, and AIDS. Bone marrow transplantation is the only curative […]