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A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia

Stroma is a poorly defined non-parenchymal component of virtually every organ with key roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma have defined individual populations in the stem cell niche regulating hematopoietic regeneration and capable of initiating leukemia. Here, we use single-cell RNA sequencing (scRNA-seq) to define a cellular taxonomy […]

‘Cancerland’ Review: Reason to Hope

“For all the insight he offers into the hard science and thorny logistics of studying cancer, Dr. Scadden’s most moving passages consider the effect of the disease on the people who suffer from it and those who care for them.” ―The Wall Street Journal Reviews & Acknowledgements: Wall Street Journal Nature International Journal of Science […]

Tackling blood diseases, immune disorders

Harvard University has completed a license agreement with Magenta Therapeutics, a startup company recently launched in Cambridge, for a portfolio of technologies with the potential to transform blood stem cell transplants from a “treatment of last resort” into a safer, more efficient therapy for patients with blood diseases and immune disorders. To date, even at […]

Colorful clones track stem cells

Harvard Stem Cell Institute (HSCI) researchers have used a colorful cell-labeling technique to track the development of the blood system and trace the lineage of adult blood cells traveling through the vast networks of veins, arteries, and capillaries back to their parent stem cells in the marrow. Developed at Harvard’s Center for Brain Science, the […]

New strategy identified for treating acute myeloid leukemia

A multi-institutional academic and industry research team led by investigators from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute has identified a promising new approach to the treatment of acute myeloid leukemia (AML). In their report published online in Cell, the investigators identify a crucial dysfunction in blood cell development that underlies AML and […]

David Scadden, MD, to Present the 2016 American Society of Hematology E. Donnall Thomas Lecture

(WASHINGTON, August 4, 2016) The American Society of Hematology (ASH) will honor David Scadden, MD, of Massachusetts General Hospital and Harvard Medical School with the 2016 E. Donnall Thomas Lecture and Prize for his work on the bone marrow hematopoietic microenvironment. This lectureship and prize is named after the late Nobel Prize laureate and past president […]

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