• David Scadden Principal Investigator

    David Scadden is the Gerald and Darlene Jordan Professor of Medicine at Harvard University.  He and Professor Douglas Melton founded and jointly direct the Harvard Stem Cell Institute that is the largest

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  • Ninib Baryawno PhD Postdoctoral Fellow

    Ninib’s Main interest is to study the hematopoietic & neural stem cell niche in context of malignancy, with the approach of single-cell RNA sequencing.

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  • Adrian Berg
    Adrian Berg Lab Technician
  • Phillip Chea Lab Technician

    Phillip’s research is focused on the metabolic plasticity of hematopoiesis and leukemogenesis. Using high-throughput functional genomic data, he aims to identify and investigate multiple metabolic pathways that may be involved in the maintenance of hematopoietic stem cells and leukemia cells.

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  • Man Cheuk-Him PhD Postdoctoral Fellow

    Man’s research focuses on studying the mechanism of the aberrant regulation of intracellular pH and potential therapeutic targets via pH manipulation in acute myeloid leukemia (AML), a fatal and heterogeneous disease with a low cure rate despite the establishment of current treatment strategies, such as conventional chemotherapy & bone marrow transplantation.

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  • Karin Gustafsson PhD Postdoctoral Fellow

    Karin’s research is focused on how hematopoietic tissues respond to and regenerate after assaults. Her primary interests are repair of the thymic microenvironment after bone marrow transplantation and bone marrow niche responses to chronic inflammation.

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  • Kevin Harrington
    Kevin Harrington Faculty Assistant
  • Youmna Kfoury PhD Instructor

    Youmna is interested in understanding how the bone marrow microenvironment contributes to hematopoietic malignancies. For this, She uses myelodysplastic syndrome as a progressive hematopoietic disease that can evolve into acute myelogenous leukemia & where there is an urgent need for new therapeutic strategies.

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  • Francois Mercier MD Instructor

    Francois research aims to better understand how leukemic stem cells gradually adapt in vivo to outcompete normal hematopoiesis, and how to revert this. To achieve this, I developed: 1) reporter systems of leukemic clonal evolution in vivo, for better functional characterization, and 2) whole-genome screening systems that use CRISPR/Cas9 technology in vivo. The overall goal of both projects is to identify new therapeutic targets.

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  • Toshihiko Oki MD, PhD Postdoctoral Fellow

    Toshihiko Oki (@tokitky) is a physician-scientist trained in the laboratory of Prof. Toshio Kitamura, working on the leukemia-projects aiming to figure out drug resistance mechanisms of leukemia with the imaging technology in Dr. Charles Lin’s laboratory & the biosensors that he developed.

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  • Catherine Rhee, PhD Postdoctoral fellow

    Since Cathy enjoys tackling difficult problems and is interested in blood cell development, she decided to broaden her academic and stem cell experience in hematopoiesis. She joined the Scadden lab in 2017 and is currently working on a project to examine epigenetic regulation of hematopoietic stem cell heterogeneity in multiple contexts.

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  • Eliza Scadden Research Technician

    Eliza joined the MGH/HMS research community in the Scadden laboratory at the end of November 2016. Arriving after studies at the University of Pennsylvania, Eliza seeks to expand her enthusiasm for biochemistry into the biomedical field and translational areas of medical research. Ultimately, Eliza plans to continue pursuing the Physician-Scientist path, as she considers the avenues of both MD/PhD and MD educational training.

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  • Amir Schajnovitz PhD Postdoctoral Fellow

    Amir’s research focuses on integrating live animal imaging & high-throughput omics technologies for the identification & validation of biologically active pathways regulating leukemia cell survival & drug-resistance.

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  • Nicolas Severe PhD Postdoctoral Fellow

    Nicolas’s research focuses on defining bone marrow stromal cell heterogeneity at single cell proteomic resolution to better understand the supporting role of the bone microenvironment during malignancies.

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  • Nisarg Shah PhD Postdoctoral Fellow

    Nisarg is interested in using synthetic and natural biomaterials to drive the reconstitution of the adaptive immune system after HSCT. Nisarg received his PhD in Chemical Engineering from MIT

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  • Azeem Sharda
    Azeem Sharda Lab Manager
  • Lev Silberstein MD PhD Instructor

    Lev is interested in combining single cell analysis tools with positional information of cells within the tissue in order to dissect the molecular milieu of the bone marrow niche and identify novel extrinsic regulators of hematopoiesis.

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  • David Sykes MD, PhD Instructor

    David’s research is focused on developing new therapies for patients with acute myeloid leukemia. To this end, they are using a combined approach of small molecule screening and genetic manipulation to understand how leukemic cells remain frozen in an immature and self-renewing state.

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  • Lisa M. Tramontozzi Program Manager for Dr. Scadden & his Laboratories

    Lisa graduated from Bryant University in 2005 with a Bachelor of Science in Business Administration majoring in Marketing Communication.  Unknowingly she would find her true passion in the health science

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  • Nick Van Gastel PhD Postdoctoral Fellow

    In every cell, a huge network of metabolic pathways works behind the scene to support cellular function. In Nick’s research, He aims to understand how these pathways control hematopoiesis, & how they are altered in the setting of leukemia.

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  • Yiping Wang Research Fellow

    Yiping’s research is focused on understanding how mitochondria metabolism is reshaped during leukemogenesis and identifying potential metabolic vulnerabilities of leukemia.

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  • Xiao-jing Yan MD, PhD Postdoctoral Fellow

    Xiaojing is interested in the epigenetic regulation in the normal & malignant hematopoiesis. She is trying to focus on two projects:

    1) to investigate the effects of epigenetic regulation gene mutations on clonal diversity.

    2) to investigate the biological function of lncRNA in the hematopoiesis.

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  • Ting Zhao
    Ting Zhao Postdoctoral Fellow
Lab Alumni Years Currently
Alexa Carver 2015-2017 Medical Student, Northwestern University Feinberg School of Medicine
Dongjun Lee, Ph.D. 2011-2017 Assistant Professor, Pusan National University School of Medicine
Ani Papazian 2015-2017 Lab Manager, David Sykes Laboratory / Massachusetts General Hospital
Rahul Palchaudhuri, Ph.D. 2011-2016 Scientist, Magenta Therapeutics
Katrina Maxcy 2014-2016 Graduate Student, University of Chicago
Jorg Dietrich MD, Ph.D. 2010-2015 Assistant Professor, Harvard Medical School / Massachusetts General Hospital
Jonathan Hoggatt, Ph.D. 2011-2015 Assistant Professor, Harvard Medical School / Massachusetts General Hospital
Julien Cobert, MD 2011-2012 Medical Resident, U Penn
Christine Ragu, Ph.D. 2010-2012 Clinical Research Associate, Paris, France
Andrew Lane, MD, Ph.D. 2010-2011 Assistant Professor, Harvard Medical School
Ying-Hua Wang, Ph.D. 2009-2015 Investigator, Regeneron
Jorg Dietrich MD, Ph.D. 2009-2014 Assistant Professor, Harvard Medical School
Francesca Ferraro, MD, Ph.D. 2009-2012 Clinical Fellow, Washington University
Stephen Sykes, Ph.D. 2009-2012 Assistant Professor, Fox Chase/Temple University
Gerd Bungartz, Ph.D. 2009-2011 Staff Scientist, Pfizer
Stephania Lymperi, Ph.D. 2009-2011 Scientific Advisor for Bioethics, Greek Gov’t
Sanket Acharya 2009-2011 Ph.D. Student, Harvard Medical School
Rushdia Z. Yusuf, MD 2008-2014 Instructor, Harvard Medical School
Siyi Zhang, Ph.D. 2008-2009 Third Rock Ventures
Vionnie Yu, Ph.D. 2007-2015 Staff Scientist, Novartis Institute for Biologic Research
Marc Raajimakers, MD, Ph.D. 2007-2010 Assistant Professor, Erasmus University, Rotterdam
Dongsu Park Ph.D. 2007-2014 Assistant Professor, Baylor College of Medicine
Borja Saez, Ph.D. 2007-2014 Assistant Professor, University of Pamplona
Daniela Krause, MD, Ph.D. 2007-2014 Assistant Professor, University of Frankfurt
Andre Catic, MD, Ph.D. 2007-2014 Assistant Professor, Baylor College of Medicine
Stephanie Xie, Ph.D. 2007-2010 Research Fellow, University of Toronto
Cris Lo Celso, Ph.D. 2006-2009 Lecturer, Imperial College, London
Shangqin Guo, Ph.D. 2006-2008 Assistant Professor, Yale Medical School
Brian Garrison, Ph.D. 2006-2009 University of California, Davis
Siddhartha Mukherjee, MD, Ph.D. 2004-2009 Assistant Professor, Columbia University
Purton Louise Ph.D. 2004-2007 Associate Professor, The University of Melbourne and Associate Director, St. Vincent’s Institute of Medical Research, Melbourne, Australia
Viktor Janzen 2003-2007 Assistant Professor, University of Bonn, Germany
Heather Fleming 2003-2007 Editor, Cell Stem Cell
 Jonas Larsson, MD, Ph.D.  2003-2006  Associate Professor, University of Lund, Sweden
Richard Haspel, MD, Ph.D. 2003-2005 Assistant Professor, Harvard Medical School, Beth Israel/Deaconess Hospital
Tong Chen MD 2003-2005 Associate Director and Professor, Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China
Dorothy Sipkins, MD, Ph.D. 2003-2004 Associate Professor, Duke University
Keith Orford, MD, Ph.D. 2002-2007 Director, GlaxoSmithKline
Eyal Attar, MD 2001-2005 Program director, Agios Pharamceuticals
Paul Robertson 2001-2004 Senior SHO in Infectious Diseases, Gartnavel Hospital, Edinburgh
Randolf Forkert, MD 2001-2004 Medinische Universitaetspoliklinik Bonn, Germany
Zbigniew Szczepiorkowski MD, Ph.D. 2000-2002 Associate Professor, Dartmouth Medical School
Henry Y Dong, MD, Ph.D. 2000-2002 Dir, Molecular Pathology, IMPATH, New York NY
Yoriko Saito, MD 1999-2006 Senior Researcher, Riken Research Center for Allergy & Immunology, Yokohama-City, Japan
Gregor Adams, Ph.D. 1999-2003 Associate Professor, University of Southern California
Sebastian Stier, MD 1999-2001 Director of Hematology, University of Bonn, Germany
Kenneth Cohen, MD 1999-2001 Assistant Professor, University of Chicago
Leonor Sarmento B.S. 1999-2000 University of Lisboa, Portugal
Paula O’Connor MD 1999-2000 Program Leader, Onyx Pharmaceuticals
Zhengyu Wang, Ph.D. 1998-2005 Johns Hopkins University
Patrick John Whelan MD, Ph.D. 1998-2004 Assistant Professor, University of Southern California
Neil Rodrigues 1998-2003 Assistant Professor, Boston University
Nobuyuki Miura MD, Ph.D. 1998-2000 Professor, Kokushikan University, Japan
Richard Evans MD 1998-2000 Senior Lecturer, University of Wales
Mark Poznansky MD, Ph.D. 1998-2001 Associate Professor, Harvard Medical School
Brander Christian Ph.D. 1997-2000 Principal Investigator, AIDS Institute, Barcelona, Spain
Byeonhg-Chel Lee Ph.D. 1996-2000 Assistant Professor, University of Pittsburgh
Jason Gardner Ph.D. 1996-1998 Senior V.P., Glaxo, Smith, Kline Pharmaceuticals
Taijiro Ishiyama MD 1996-1997 Showa Univ. Sch. Of Med., Japan
Antonio Daga MD, Ph.D. 1996-1997 University of Genoa, Italy
Nadia Carlesso MD, Ph.D. 1995-2001 Associate Professor, University of Indiana
Tao Cheng MD 1994-2000 Professor, University of Pittsburgh
Hongmei Shen Ph.D. 1994-1999 Associate Professor, University of Pittsburgh
Michael Franken MD 1993-1995 Vice President, Genzyme Corporation
Andrew Freedman MD, Ph.D. 1993-1994 Consultant, University of Cardiff, Wales, UK
David Feder MD 1992-1994 Research Fellow, McGill Univ. (now deceased)
Anna Berardi Ph.D. 1992-1994 Laboratories of Transfusion Medicine, Santo Spirito Hospital, Pescara, Italy