Amir is currently an HMS faculty instructor in medicine, conducting his studies with Prof. David Scadden at the Harvard Department of Stem Cell and Regenerative Biology, Harvard University.
Amir has a PhD from the Weizmann Institute of Science, where he studied the cross talk regulatory mechanisms between the bone marrow microenvironment and the molecular biology of normal hematopoiesis, stem cell mobilization and transplantation, under the supervision of Prof. Tsvee Lapidot.
In the Scadden laboratory his research is focused on leukemia; a malignant disease of blood stem and progenitor cells, which causes accumulation of cancer cells in the bone marrow that impairs normal blood formation. Current anti-leukemia therapies can result in disease remission – however, relapse is common due to a few drug-resistant cells.
He has optimized in vivo imaging techniques, which enable high precision systemic monitoring of disease progression and response to treatment. Combined with intravital microscopy, flow cytometry and high throughput bioinformatic analyses Amir is investigating how residual drug-resistant leukemia cells evade conventional therapeutic strategies.