Nicolas Severe, Ph.DPostdoctoral Fellow

Education: B.Sc in Molecular and Cellular Biology at University of Rennes 1, Rennes, France; M.Sc in Bone Biology, Physiology and Pathology at University Paris-Diderot, Paris, France; Ph.D in Biology specialization in bones, joints and biomaterials in calcified tissues at University Paris-Diderot, Paris, France.

Specialties: Mass Cytometry, bone histology, reporter mouse models, bone metastatic models.

Field: Bone marrow niche, bone metastatic microenvironment.

Background and project: Nicolas earned with honors his Ph.D in 2011 at the University Paris-Diderot (Paris VII-France) under the mentorship of Dr. Pierre Marie (Laboratory INSERM U606). During his master degree and his Ph.D, He acquired knowledge on bone biology and pathology. He has provided novel insights into the molecular signals involved in the osteogenic differentiation of mesenchymal cells and bone cancer cells. More specifically, He was studying the functional regulation of tyrosine kinase receptors degradation mediated by the ubiquitin ligase c-Cbl in A) human mesenchymal stromal cells differentiation into osteoblasts (Severe et al., JBC 2011) but also in B) bone tumor formation and colonization (Severe et al., JBMR 2012).

Nicolas joined the Dr. Scadden’s laboratory for his postdoctoral training to pursue his learning in the bone field. He is interested to better define the supportive role of osteolineage cells in regulation of hematopoietic diseases and bone metastases development.

He is currently using emerging technologies and reporter mouse models to characterize the bone marrow niche heterogeneity at single-cell proteomic level & looking at changes in specific subsets of bone marrow stromal cells after genotoxic stress but also during disease development within the bone marrow microenvironment. 

Grant: The French Medical Foundation (FRM) and the American Association for Cancer Research (AACR) have supported me during my postdoctoral training.

Professional membership: Nicolas is a member of the American Association for Cancer Research (AACR), the Tumor Microenvironment Network (TMEN) and the International Bone and Mineral Society (IBMS) in order to connect and interact with experts in the bone tumor microenvironment field.