Yiping Wang received his PhD in Biochemistry and Molecular Biology from Fudan University in 2014, under the supervision of Dr. Yue Xiong and Dr. Kunliang Guan. In his previous work, he focused on how cellular metabolism interacts with epigenetics and stress response. Through exploring mutual exclusive mutations in leukemia genome, he discovered IDH1/2-TET2-WT1 pathway, in which transcription factor WT1 recruits methylcytosine dioxygenase TET2 to specific genomic locus and suppresses leukemia cell proliferation (Wang et al. Mol Cell. 2015). Also, he demonstrated how cells coordinate their metabolic activity with redox status through post-translational regulatory mechanisms (Wang et al. EMBO J. 2014; Wang et al. Mol Cell. 2016).
The renaissance of metabolism is unexpectedly and rapidly advancing our knowledge of cancer biology and stem cell biology. Yiping joined Dr. Scadden’s laboratory as a research fellow to pursue his interest in leukemia metabolism. As a powerhouse within cells, mitochondria not only functions as an energy factory, but also actively participate in cell signaling and epigenetic regulation. Yiping is investigating how mitochondria metabolism is reshaped during leukemogenesis and aims towards identifying potential metabolic vulnerabilities of leukemia.