T E A M
  • David Scadden, M.D. Principal Investigator

    Dr. David Scadden is the Gerald and Darlene Jordan Professor of Medicine at Harvard University.  He and Professor Douglas Melton founded and jointly direct the Harvard Stem Cell Institute.

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  • Trine Ahn Kristiansen, PH.D Postdoctoral Fellow

    Trine’s research questions are focused on the interplay between a changing bone marrow niche and blood disease. How are the responses at this interface changed with past and upon present stress exposures? Can niche heterogeneity shape clone-specific response patterns with impact on disease progression and infection?

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  • Tsuyoshi Fukushima, PH.D Postdoctoral Fellow

    Tsuyoshi is interested in the regulatory mechanisms of hematopoietic stem cell fate branching. He is currently studying lineage branch tracing and branching regulation using DNA random barcodes and CRISPR-Cas9 screening in vivo.

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  • Christina Mayerhofer, M.D. Postdoctoral Fellow

    Christina is a physician scientist with a clinical and research focus on pediatric hematology and oncology. She joined the Scadden lab in 2021 and investigates the role of leukemia stem cells in causing disease and relapse by integrating metabolic approaches.
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  • Juan Bautista Menendez-Gonzalez, Ph.D Postdoctoral Fellow

    Juan is interested in exploiting unique metabolic properties that cells acquire to initiate and maintain disease. He is currently developing novel therapies that modulate cellular bioenergetics in leukemia and non-hematologic diseases.
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  • Lingli He, Ph.D Postdoctoral Fellow

    Lingli is interested in exploiting the metabolic vulnerabilities of malignant myeloid cells to develop small molecules for therapy. Through the study of malignancy, she also seeks to determine what normal cells must protect to preserve the integrity of the blood system.
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  • Karin Gustafsson, Ph.D Instructor

    Karin’s research is focused on how hematopoietic tissues respond to and regenerate after assaults. Her primary interests are repair of the thymic microenvironment after bone marrow transplantation and bone marrow niche responses to chronic inflammation.

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  • Taghreed Hirz, Ph.D Postdoctoral Fellow

    Taghreed is interested in understanding the biology of prostate cancer and the complexity of disease bone metastasis. Using scRNA-sequencing, she aims to compare low grade vs. high grade primary prostate tumors and to identify the molecular regulators at the interface of prostate cancer metastatic cells and the bone marrow niche.

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  • Michael Mazzola Graduate Student

    Michael is a Ph.D.student in the Biological and Biomedical Sciences Program at Harvard University. During his graduate studies, he hopes to better understand how the fetal liver and bone marrow niches support stem cell identity and heterogeneity. Michael is particularly interested in post-transcriptional mechanisms that govern stem cell self-renewal.

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  • Azeem Sharda
    Azeem Sharda Lab Manager
  • Lisa M. Tramontozzi Program Manager for Dr. Scadden & his Laboratories

    Lisa graduated from Bryant University in 2005 with a Bachelor of Science in Business Administration majoring in Marketing Communication.  Unknowingly she would find her true passion in the health science

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  • Ting Zhao, Ph.D Postdoctoral Fellow

    Ting is interested in leveraging the power of the chemical approach to modulate cell fate to develop potential therapeutic strategies for cancer treatment and regenerative medicine. He is currently seeking to develop differentiation therapy to osteosarcoma.

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A L U M N I
Lab Alumni End Date Currently
Tiancheng Fang, Ph.D 2022 Scientist, Bristol Myers Squibb
Giulia Schiroli, Ph.D 2022 Senior Scientist, Tessera Therapeutics, Boston
Konstantinos Kokkaliaris, Ph.D 2022 Group Leader, University Hospital Frankfurt & Goethe University
Catherine Rhee, Ph.D 2022 Senior Scientist, AstraZeneca
Youmna Kfoury, Ph.D 2021 Senior Scientist, Moderna, USA
Eliza Scadden 2021 Senior Scientist, Novertis Institute for Biomedical Research
Wei Zhong Leong, Ph.D 2020 Senior Scientist, Carmine Therapeutics, USA
Nick Van Gastel, Ph.D. 2020 Group Leader, de Duve Institute, Belgium
Nicolas Severe, Ph.D 2019 Senior Scientist, Pyxis Oncology, USA
Yiping Wang, Ph.D. 2019 Assistant Professor, Fudan University, China
Cheuk Him Man, Ph.D. 2019 Assistant Professor, University of Hong Kong
Toshihiko Oki, MD, Ph.D. 2018 Associate Medical Director, Takeda Pharmaceutical
Adrian Berg 2018 Medical Student, University of Vermont
Ninib Baryawno, Ph.D. 2017 Assistant Professor, Karolinska Institute
Francois Mercier, MD 2017 Assistant Professor, McGill University
Lev Silberstein, MD, Ph.D. 2017 Assistant Professor of Medicine, University of Washington
David Sykes, MD, Ph.D. 2017 Principal Investigator, Massachusetts General Hospital
Alexa Carver 2017 Medical Student, Northwestern University Feinberg School of Medicine
Dongjun Lee, Ph.D. 2017 Assistant Professor, Pusan National University School of Medicine
Ani Papazian 2017 Medical Student, Tufts University
Rahul Palchaudhuri, Ph.D. 2016 Director of Biotherapeutics, Magenta Therapeutics
Katrina Maxcy 2016 Graduate Student, University of Chicago
Jonathan Hoggatt, Ph.D. 2015 Director of Hematology, Moderna Therapeutics
Ying-Hua Wang, Ph.D. 2015 Investigator, Regeneron
Vionnie Yu, Ph.D. 2015 Principal Investigator, Novartis Institutes for BioMedical Research
Jorg Dietrich MD, Ph.D. 2014 Assistant Professor, Harvard Medical School / Massachusetts General Hospital
Rushdia Z. Yusuf, MD 2014 Merck Pharmaceuticals
Dongsu Park, Ph.D. 2014 Assistant Professor, Baylor College of Medicine
Borja Saez, Ph.D. 2014 Assistant Professor, University of Pamplona
Daniela Krause, MD, Ph.D. 2014 Assistant Professor, University of Frankfurt
Andre Catic, MD, Ph.D. 2014 Assistant Professor, Baylor College of Medicine
Christine Ragu, Ph.D. 2012 Clinical Research Associate, Paris, France
Julien Cobert, MD 2012 Medical Resident, U Penn
Francesca Ferraro, MD, Ph.D. 2012 Clinical Fellow, Washington University
Stephen Sykes, Ph.D. 2012 Assistant Professor, Fox Chase/Temple University
Gerd Bungartz, Ph.D. 2011 Staff Scientist, Pfizer
Andrew Lane, MD, Ph.D. 2011 Assistant Professor, Harvard Medical School
Stephania Lymperi, Ph.D. 2011 Scientific Advisor for Bioethics, Greek Gov’t
Sanket Acharya 2011 Ph.D. Student, Harvard Medical School
Marc Raajimakers, MD, Ph.D. 2010 Professor, Erasmus University, Rotterdam
Stephanie Xie, Ph.D. 2010 Research Fellow, University of Toronto
Siyi Zhang, Ph.D. 2009 Third Rock Ventures
Cris Lo Celso, Ph.D. 2009 Professor, Imperial College, London
Brian Garrison, Ph.D. 2009 University of California, Davis
Siddhartha Mukherjee, MD, Ph.D. 2009 Assistant Professor, Columbia University
Shangqin Guo, Ph.D. 2008 Assistant Professor, Yale Medical School
Keith Orford, MD, Ph.D. 2007 Chief Medical Officer, Calithera
Purton Louise, Ph.D. 2007 Associate Professor, The University of Melbourne and Associate Director, St. Vincent’s Institute of Medical Research, Melbourne, Australia
Viktor Janzen 2007 Assistant Professor, University of Bonn, Germany
Heather Fleming 2007 Editor, Cell Stem Cell
 Jonas Larsson, MD, Ph.D.  2006 Professor, University of Lund, Sweden
Yoriko Saito, MD 2006 Senior Researcher, Riken Research Center for Allergy & Immunology, Yokohama-City, Japan
Zhengyu Wang, Ph.D. 2005 Assistant Professor, Johns Hopkins University
Eyal Attar, MD 2005 Program director, Agios Pharamceuticals
Richard Haspel, MD, Ph.D. 2005 Associate Professor, Harvard Medical School
Tong Chen, MD 2005 Associate Director and Professor, Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China
Dorothy Sipkins, MD, Ph.D. 2004 Associate Professor, Duke University
Paul Robertson 2004 Senior SHO in Infectious Diseases, Gartnavel Hospital, Edinburgh
Randolf Forkert, MD 2004 Medinische Universitaetspoliklinik Bonn, Germany
Patrick John Whelan, MD, Ph.D. 2004 Assistant Professor, University of Southern California
Neil Rodrigues 2003 Assistant Professor, Boston University
Gregor Adams, Ph.D. 2003 Kite Pharmaceuticals
Zbigniew Szczepiorkowski, MD, Ph.D. 2002 Professor, Dartmouth Medical School
Henry Y Dong, MD, Ph.D. 2002 Dir, Molecular Pathology, IMPATH, New York NY
Sebastian Stier, MD 2001 Director of Hematology, University of Bonn, Germany
Kenneth Cohen, MD 2001 Assistant Professor, University of Chicago
Mark Poznansky, MD, Ph.D. 2001 Associate Professor, Harvard Medical School
Nadia Carlesso MD, Ph.D. 2001 Professor, City of Hope
Leonor Sarmento 2000 University of Lisboa, Portugal
Paula O’Connor, MD 2000 Executive Vice President, Clinical Development and Medical Affairs, Coherus
Nobuyuki Miura, MD, Ph.D. 2000 Professor, Kokushikan University, Japan
Richard Evans, MD 2000 Senior Lecturer, University of Wales
Tao Cheng, MD 2000 Director, Institute of Hematology ; Chinese Academy of Medical Sciences and Peking Union Medical College
Brander Christian, Ph.D. 2000 Principal Investigator, AIDS Institute, Barcelona, Spain
Byeonhg-Chel Lee, Ph.D. 2000 National Institutes of Health, USA
Hongmei Shen, Ph.D. 1999 Research Associate Professor of Surgery, University of Pittsburgh
Jason Gardner, Ph.D. 1998 CEO, Magenta Therapeutics
Taijiro Ishiyama, MD 1997 Showa Univ. Sch. Of Med., Japan
Antonio Daga MD, Ph.D. 1997 University of Genoa, Italy
Michael Franken, MD 1995 CEO, Red Oak Medicines
Andrew Freedman, MD, Ph.D. 1994 Consultant, University of Cardiff, Wales, UK
David Feder, MD 1994 McGill Univ. (now deceased)
Anna Berardi, Ph.D. 1994 Laboratories of Transfusion Medicine, Santo Spirito Hospital, Pescara, Italy