During his academic studies Juan became fascinated by metabolism and undertook undergraduate training at Prof. Kamil Kranc’s group (University of Edinburgh) to investigate hypoxia signaling pathways in hematopoietic and leukemic stem cells.
In October 2014 he joined Dr. Neil Rodrigues’ laboratory at the European Cancer Stem Cell Research Institute (Cardiff University) to pursue a PhD exploring the role of transcription factor GATA2 in normal and malignant hematopoiesis. His studies unveiled a critical role for GATA2 in leukemia stem cell survival and differentiation, and found novel candidate genes that regulate leukemia stem cell fate decisions.
In November 2020 he moved to Dr. Jonathan Hoggatt’s lab (MGH) to study the properties of hematopoietic stem cell with better engraftment ability with the aim to find new therapies to improve stem cell transplantation. In March 2021 he joined Dr. David Scadden’s laboratory and is currently working on a project to modulate cellular bioenergetics to treat leukemia and non-malignant diseases.